The Southern Flinders Ranges wine region is at the southern extremity of the Far North wine zone and is its only region. The Spencer Gulf marks the western edge of the region, which is sandwiched between The Peninsulas wine zone to the west and The Mount Lofty Ranges wine zone to the southeast. The drive from Adelaide takes around two-and-a-half hours.

The region is popular with campers and tourists and the Mount Remarkable National Park is a big draw card.

The area emerged as a wine-growing region in the last two decades of the 20th century and is a natural extension of the Clare Valley, with which it shares many geological factors. Its climate is warm, with most vineyards requiring irrigation from underground sources. The soil is fertile and quite suitable for viticulture.

Most of the vineyards are established on the slopes of the Flinders Ranges at around 350-550 metres. This attitude and the sea breezes from the Gulf temper the hot climate.

The area has many of the mainstream varietals planted, which are used to produce wines at the small number of cellar doors in the region, but generally focuses on exporting Shiraz, Cabernet Sauvignon and Merlot to the Barossa Valley.